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Zapecine®

Name: Zapecine (capecitabine) film-coated tablets.

Active Substance: capecitabine

Stengths: 150 mg, 500 mg

Description: Zapecine (capecitabine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Use in Cancer: Zapecine (capecitabine) is approved to treat:

  • Colon (large bowel) cancer. Capecitabine is used with or without other cancer medicines in patients who have had surgery for ‘stage III’ or ‘Dukes’ stage C’ colon cancer.
  • Metastatic colorectal cancer.
  • First-line treatment of advanced gastric cancer in combination with a platinum-based regimen.
  • Locally advanced or metastatic breast cancer Capecitabine is used with docetaxel after treatment with anthracyclines has failed. It can also be used on its own when treatment with both anthracyclines and taxanes has failed or when repeat treatment with anthracyclines is not suitable for the patient…

Important: The drug information on this page is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.

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